Clinical significance of monocyte chemoattractant protein-1, tissue factor in elderly patients with acute exacerbation of chronic obstructive pulmonary disease
10.3760/cma.j.issn.1673-4904.2013.19.001
- VernacularTitle:老年慢性阻塞性肺疾病急性加重患者单核细胞趋化蛋白-1、组织因子的临床意义
- Author:
Yong WANG
;
Ning DING
;
Yanling ZHAI
;
Fuqiang LIU
;
Yi ZHENG
- Publication Type:Journal Article
- Keywords:
Pulmonary disease,chronic obstructive;
Thromboplastin;
Monocyte chemoattractant proteins;
Procalcitonin
- From:
Chinese Journal of Postgraduates of Medicine
2013;(19):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels and clinical significance of monocyte chemoattractant protein (MCP)-1 and tissue factor (TF) in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods Forty-nine elderly patients with AECOPD(AECOPD group) and 30 healthy controls (control group) were selected,and AECOPD group was divided into procalcitonin (PCT) increased group (PCT ≥ 0.5 μ g/L,19 cases) and PCT normal group (PCT ＜ 0.5 μ g/L,30 cases) according to the level of serum PCT.The levels of plasma TF,serum MCP-1 and PCT were determined by enzyme linked immunosorbent assay.Results The levels of plasma TF and serum MCP-1 were (203.6 ± 92.9),(152.8 ±99.9) ng/L in AECOPD group,and (136.9 ±24.3),(87.5 ±41.5) ng/L in control group.There were significant differences in the levels of plasma TF and serum MCP-1 between AECOPD group and control group (P＜0.01).The level of plasma TF was positively correlated with serum MCP-1 (r =0.673,P=0.029).The levels of plasma TF and serum MCP-1 were (215.3 ±71.2),(181.1 ±61.6) ng/L in PCT increased group,and (192.4 ±79.7),(137.3 ±74.4) ng/L in PCT normal group.There were significant differences in the levels of plasma TF and serum MCP-1 between PCT increased group and PCT normal group (P＜0.05).Conclusions In patients with AECOPD,hypercoagulability state is activated,and it is more severe in the patients with increased PCT.The level of plasma TF is positively correlated with serum MCP-1 in patients with AECOPD.To monitor the levels of plasma TF and serum MCP-1 is particularly important for elderly patients of AECOPD with hypercoagulability state to prevent cardiovascular,lungs and cerebrovascular thrombotic disease.
