Titanium implants:Strategies on surface modification and effect on osseointegration
10.3969/j.issn.2095-4344.2013.29.020
- VernacularTitle:钛种植体表面改性策略及对骨整合的影响*☆
- Author:
Ying LI
;
Changyi LI
- Publication Type:Journal Article
- Keywords:
biomaterials;
biomaterial review;
tissue-engineered bone materials;
oral implant materials;
titanium;
implants;
surface modification;
osseointegration;
physical modification;
chemical modification;
biochemical modification;
provincial grants-supported paper
- From:
Chinese Journal of Tissue Engineering Research
2013;(29):5395-5402
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND:Titanium has been widely used in dental implantation because of its good biocompatibility, mechanical properties and its similar elastic modulus to the bone. OBJECTIVE:To summarize three strategies for surface modification of titanium implants:physical modification, chemical modification and biochemical modification. METHODS:PubMed and CNKI databases were searched for articles published from January 2007 to February 2013, and the key words were“titanium, implant, surface modification, osseointegration”in English and Chinese, respectively. Articles which are closely related to titanium implant surface modification and osseointegration were included, and repetitive articles were removed. RESULTS AND CONCLUSION:After preliminary search, 199 articles were found. According to the inclusion criteria and exclusion criteria, 76 articles were further analyzed. Titanium implant is a bioinert material, and thus the researchers focus on surface modification to activate the titanium implant so as to possess biological function and achieve early osseointegration. Implant surface modification strategies include three perspectives:physical modification, chemical modification and biochemical modification which can shorten the period of implant therapy and achieve early osseointegration and higher binding strength. The future research trend is to combine three strategies and to further explore the molecular basis of mechanism at the interface between implant and organism cel and the tissue in order to use better surface modification technology to fulfil the early and more stable osseointegration between the implant and bone tissue.
