Gene expression spectra in human hepatoma SMMC-7721 cells treated with gambogic acid
- VernacularTitle:藤黄酸对人肝癌细胞株SMMC-7721的基因表达谱的影响
- Author:
Na LU
;
Hongyan GU
;
Qidong YOU
;
Yong YANG
;
Qinglong GUO
- Publication Type:Journal Article
- Keywords:
gambogic acid;
microarray;
primary hepatocellular carcinoma
- From:
Journal of China Pharmaceutical University
2007;(5):424-428
- CountryChina
- Language:Chinese
-
Abstract:
Aim: To investigate gene expression spectra in human hepatoma cell line SMMC-7721 treated with gambogic acid (GA).Methods:Human cDNA microarray and RT-PCR technology were used to detect the changes in gene expression. Results: 31 genes in groups exposed to gambogic acid for 24 h and 56 genes for 48 h group were expessed differentially in comparison to the control group. Conclusior:The antitumor mechanism of GA might focus on apoptosis,metastasis as well as interfering with the cell cycle.
