Influence of Ratios of Drug to Lipid on the Characteristics of Solid Lipid Nanoparticles Containing Mifepristone
- VernacularTitle:药脂比对米非司酮固体脂质纳米粒性能的影响
- Author:
Dongzhi HOU
;
Changsheng XIE
;
Changhong ZHU
- Publication Type:Journal Article
- Keywords:
Solid lipid nanoparticles;
Ratio of drug to lipid;
Entrapment efficiency;
Laser diffractometry;
Differential scanning calorimetry
- From:
Journal of China Pharmaceutical University
2005;(1):22-26
- CountryChina
- Language:Chinese
-
Abstract:
AIM:The effective abortifacient drug,mifepristone,was incorporated in the solid lipid nanoparticles (SLNs). The aim of this paper was to study the influence of ratios of drug to lipid on the characteristics of SLNs.METHOD:The physicochemical properties of the fine dispersed systems,such as the size distribution,Zeta potential had been analyzed by laser diffractometry(LD).The measurements of entrapment efficiency(EE)and thermal analysis of DSC were performed as well.RESULT:It was showed if the weight of lipid remained unchanged,the mean particle size of SLNs increased with the increase of drug amount.Drug entrapment efficiency was the highest while about 50 mg drug was loaded on weight 1 g lipid.Simultaneously,the charge of Zeta potential agreed well with the amount of free drug in the colloidal system.DSC analysis results showed that the melting peak of mifepristone at approx.190 ℃ disappeared.CONCLUSION:It was evidence that the drug incorporation would affect the average particle size and Zeta potential of the colloidal systems and the physical state of crystalline drug mifepristone in SLNs was present in the amorphous form or molecularly dispersed at even so high adding amount of 250 mg/g(lipid),which there was no report about the physical state of the drug and SLN with so high drug-loading.It was suggested that the model drug mifepristone could influence the property of nanodispersion system and the crystalline character of the drug was altered by the nanometer carrier system vice versa.
