Chromones from Angelica morri Hayata
- VernacularTitle:福参活性成分色原酮的研究
- Author:
Shi SUN
;
Lingling XU
;
Lingyi KONG
;
Hanqing ZHANG
;
Shanan HE
- Publication Type:Journal Article
- Keywords:
Angelica morri Hayata;
Chromone;
Rat aorta;
Umbelliferae
- From:
Journal of China Pharmaceutical University
2003;(2):125-127
- CountryChina
- Language:Chinese
-
Abstract:
AIM:Bioactive constituents were expected to be obtained from the roots of Angelica morri Hayata. METHOD:They were extracted with 95% alcohol and isolated by using column chromatography and recrystallization methods. The structures were elucidated by means of physico-chemical data and UV,IR,1HNMR, 13CNMR,and EIMS. The inhibitory effect on the constriction of rat aortic rings was induced by K+ or Ca2+. RESULT:3′S-(-)-hamaudol,3′S-(-)-Ο-acetylhamaudol,3′R-(+)-hamaudol,and (±)-hamaudol were isolated from the pieces of Radix Angelica Morri. The inhibitory rate of 3′S-(-)-Ο-acetylhamaudol and (±)-hamaudol on the above pharmacologic model appears the relation of quantity response. CONCLUSION:All the above compounds were found in this species for the first time,and(±)-hamaudol is a new. One of effect mechanisms of 3′S-(-)-Ο-acetylhamaudol and (±)-hamaudol diluted aorta could contribute to be inhibiting Ca2+ influx of vascular smooth muscle.
