Investigation on Influence Factors of Dissolution of Metronidazole Tablet
10.3870/j.issn.1004-0781.2001.06.042
- VernacularTitle:甲硝唑片溶出度影响因素的探讨
- Author:
Taiyuan LU
- Publication Type:Journal Article
- From:
Herald of Medicine
2001;(6):376-377
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the factors influencing the dissolution of metronidazole tablet. Methods:CMS-Na and magnesium stearate were added with five different ratios before tabletting, respectively, mixed equally and tabletted, then the dissolution was determined; the softmaterials were made with 87℃ and 50℃ of starch as adhesion agent, and respectively, tabletting, then the dissolution was determined; tablets were experessed with the grains of different magnitude and different hardness, then the dissolution were determined same group of grains were expressed into three tablets, of which diameters were 8, 9, 10 mm respectively. Results:CMS-Na could obviously increase the dissolution of metronidazole tablet; when the temperature of starch were 87℃ and 50℃, the dissolution of metronidazole tablet were 94.55±1.67(n＝5)and 84.32±2.60(n＝5), respectively; when the grain is big, hardness is strong, the dissolution was declined when the grains were big magnitude and strong hardness, on the contrary, the dissolution was higher; the accumulated dissolution of three diameter of 8, 9, 10 mm were 98.85%, 99.64%, 99.51% respectively. Conclusion:the disintegrant had larger effect on the dissolution within 30 minutes of metronidazole tablet; the grain's magnitude and hardness and the temperature of starch had also produced and effect on the dissolution of metronidazole tablet; the magnitude of tablet's diameter had only little effect on the dissolution of metronidazole tablet.
