Influence of anisodamin on guinea pig experimental nasal hypersensitivity
10.3969/j.issn.1001-1781.2001.05.011
- VernacularTitle:山莨菪碱对豚鼠实验性鼻超敏反应的影响
- Author:
Zhihua ZHU
;
Zhen DONG
;
Zhanquan YANG
- Publication Type:Journal Article
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2001;(5):218-220
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the influence of anisodamin on guinea pig experimental nasal hypersensitivity.Method:Experimental animals were divided into normal control group, TDI group,reserpine group and anisodamine group.The scores of symptom of nose and the cytologic changes of nasal mucosa were parameters of observing.Result:The nasal symptom of reserpine group was significantly stronger than the TDI group,and the eosinophilia evidently increased (both P＜0.01).The nasal symptom of the anisodamine group reduced and the eosinophilia decreased.It is significantly difference between the TDI group and the reserpine group (both P＜0.01).Conclusion:Anisodamine may play a role in therapy of the experimental nasal hypersensitivity with hyperfuction of parasympathetic nerve.
