The Protective Effects of Tetrahydropalmatine against Hippocamp Lesion Induced by Ischemia－Reperfusion in Rats

VernacularTitle:四氢帕马汀对大鼠海马缺血再灌注损伤保护作用
Author: Qing MIN ; Jiliang WU ; Chao LIU ; Sijie SU
Publication Type:Journal Article
From: Herald of Medicine 2001;(5):284-285
CountryChina
Language:Chinese
Abstract: Objective: To study the protective effects of tetrahydropalmatine (THP) against ischemia－reperfusion induced hippocamp lesion in rats. 　MethodS: A model of ischemia-reperfusion induced brain lesion was set up by ligation of common carotid arteria in rats, and the protective effects of THP was observed.　Results: It was found that, with administration of THP, the activities of superoxide dismutase (SOD), glutathione peroxidase (GSHPx) and Na+, K+-ATPase as well as Ca2＋－ATPase were increased (P＜0.05, respectively), while malondialehyde (MDA) was decreased to 42.5% (P＜0.01) during brain ischemia－reperfusion.　Conclusion:The results suggested that THP can protect the rat against ischemia－reperfusion induced brain lesion.