Observation of Short- and Long-Term Effect of Defibrase on Acute Cerebral Infarction (39 Clinical Cases Report)
10.3870/j.issn.1004-0781.2001.05.023
- VernacularTitle:去纤酶治疗急性脑梗死疗效观察
- Author:
Xuejun DENG
;
Yuanwu MEI
;
Shenggang SUN
;
Etang TONG
- Publication Type:Journal Article
- From:
Herald of Medicine
2001;(5):305-306
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the short- and long-term effect of defibrase on acute cerebral infarction. Methods: A prospective, randomized double-blind control method was employed for the study. All the patients were treated with injection of either defibrase or placebo. The scores of neurological function deficits and daily living abilities as well as the level of fibrinogen were tested.Results: The neurological function of the patients treated with defibrase was significantly improved, the scores of daily living abilities increased, and the level of fibrinogen in blood decreased. A follow-up of the subjects at the time point of one year after the treatment revealed that, the recurrence rate of infarction in those treated with defibrase was zero. Meanwhile, the subjects treated with defibrase had significantly decreased scores of neurological function and significantly improved daily living abilities comparing with those treated with the placebo. Conclusion: Defibrase can protect the nurons against ischemia-induced lesion, improve the neuron function by decreasing the fibrinogen level. It has valid therapeutic effect on cerebral infarction.
