The effects of iron supplementation on auditory brain-stem response with iron deficiency anemia in rats

VernacularTitle:缺铁性贫血治疗前后听性脑干反应的变化
Author: Benzhong ZHOU ; Shengguo WANG ; Qiong WANG ; Aihua SUN ; Yulong MA ; Jianjun SHEN
Publication Type:Journal Article
From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2001;(4):173-175
CountryChina
Language:Chinese
Abstract: Objective:To evaluate the therapeutic methods of sensorineural hearing loss with iron deficiency anemia and their effects. Method:Sixty-eight Wistar rats were randomly divided into 3 groups: Group A (iron deficiency group A) 24 rats, group B (iron deficiency group B) 24 rats and group C (control group) 20 rats. Group A and B were fed with iron deficiency diet for 6 weeks. By analyzing ABR and DPOAE, hearing loss was detected in group A and B. Then,group A was given iron supplementation diet and hyperbaric oxygen therapies. and group B was given iron supplementation diet only. Result:The auditory thresholds and period latencies (PL) of I waves of ABR and DPOAE amplitude in 2 kHz and 3kHz within group A and B were significantly different before and after treatment (P＜0.05). But the effects of treatment between these two groups had not significant differences (P＞0.05). Conclusion: It suggested that good results can be obtained by early iron supplementation in iron deficiency hearing loss cases. Hyperbaric Oxygen therapy may not be necessary.