Pharmacokinetics of omeprazole in patients with liver cirrhosis
- VernacularTitle:奥美拉唑在肝硬化患者中的药动学研究
- Author:
Liping LIU
;
Zhenman WEI
;
Chengshan HE
;
Xiaodong SUN
;
Yonggang LI
;
Weihong TANG
- Publication Type:Journal Article
- From:
Chinese Pharmaceutical Journal
2001;(4):259-261
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To study the pharmacokinetics of omeprazole (OME) in 8 patients with liver cirrhosis.METHODS The plasma concentrations of OME were determined by HPLC,and the pharmacokinetic parameters were computed by using 3P97 program.RESULTS The plasma concentration versus time curve following intravenous 40 mg OME in patients with liver cirrhosis was coincident with two-compartment model.The elimination half-life was (3.34±0.38) h,which was longer than the value of the healthy volunteers and CLs was lower than the value of the healthy volunteers.CONCLUSION The dosage of OME may be given in the half of the routine dosage or adjusted conditionally when using for the patients with liver cirrhosis.
