Antibacterial activities of some commonly used antibiotics to 106 isolated strains of porphyromonas ginginalis in vitro
10.3969/j.issn.1671-8348.2001.03.004
- VernacularTitle:常用抗厌氧菌药物对牙龈卟啉单胞菌的体外抗菌活性研究
- Author:
Ming TANG
;
Jincai ZHANG
;
Xiaorong XIAO
;
Zhu ZHU
;
Yurong LIU
- Publication Type:Journal Article
- From:
Chongqing Medicine
2001;(3):200-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective Porphyromonas gingivalis(Pg)is one of the main putative pathogens of periodontal disease,espcially of adult periodontitis. This in vitro study was aimed at observing the inhibition actions of 3 kinds of antimicrobial drugs on Pg. Methods 106 stains of Pg were isolated from subgingival plaques with adult periodontitis. The agar diffusion test was used to detect the inhibition actions of metronidazole,clindamycin and tinidazole on 106 stains of Pg. Results Their MIC was respectively:0. 25mg/L,0. 6rng/L. The MIC90 of tinidazole＜MIC90 of clindamycin. The results showed:all of metroidazole, tinidazole and clindamycin can be used effectively against Pg,clindarnycin and tinidazole showed more potent antibacterial activity than metronidazole. The different concentration of Pg-liquid (l05 CFU/ml, 106 CFU/ml and 108 CFU/ml) had not influenced the results. Couclusion This study is significant to antibiotical therapy of periodontal diseases.
