Role of platelet activating-factor (PAF) ,tumor necrosis factor(TNF), interleuking8(IL-8)on septic rats
10.3969/j.issn.1671-8348.2001.03.006
- VernacularTitle:血小板活化因子与肿瘤坏死因子和白介素8在大鼠脓毒血症中的作用
- Author:
Dongzhu ZENG
;
Peiwu YU
- Publication Type:Journal Article
- From:
Chongqing Medicine
2001;(3):205-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of PAF, TNF, IL-8 on septic rats. Methods Made use of the model of cecum ligated and perforated, observed the mortality rate of septic rats and examined their level of blood PAF, serum TNF,IL-8 at several plastic points, analysizd the relationship between level of blood PAF and serum TNF, IL-8. Results (1)The level of blood PAF, and serum TNF,IL-8 elevated significantly. The blood PAF was positively related with serum TNF, IL-8. (2)Treated with PAF antagonist WEB2170 could reduced the level of blood PAF, serum TNF, IL-8. (3)The mortality rate of the severe infectious rats could be reduced by WEB2170. Conclusion The PAF antagonist can block the network relationship between PAF and TNF,IL-8 and has an important role on preventing MOF.
