Effects of blood transfusion on cellular immuno-function in patients with laryngeal carcinoma

VernacularTitle:术中输血对喉癌患者细胞免疫功能的影响
Author: Jie WANG ; Chunfu DAI ; Siliang LIU ; Sang WANG ; Huawen DONG ; Kuangcheng XIE
Publication Type:Journal Article
From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2001;(3):103-105
CountryChina
Language:Chinese
Abstract: Objective:To explore the influence of blood transfusion on cellular immunofunction in patient with laryngeal carcinoma.Method:EPICS-XL flow cytometry was used to measure T cell subgroup,NK cell and CD28 in 36 patients with laryngeal carcinoma pre-operation and 2 weeks post-operation.Patients were divided into allotransfusion group and non-transfusion group.Comparison was conducted between the 2 groups.Result:①Comparsion with normal population,decreasing of CD3,CD4,NK cell and CD28 in the 36 patients pre-operation was statistically significant (P＜0.01).②Decreasing of CD3,CD4,NK cell and CD28 was statistically signficant post-operation(P＜0.05).③In the non-transfusion group change of CD3,CD4,CD8,NK cell and CD28 post-operation was statistically insignificant (P＞0.05).Conclusion:While cellular immunofunction is generally low in patients with laryngeal carcinoma,allotransfusion will reduce further.It makes contribution to spreading and metastasis of carcinoma easier.