Development of Diclofenac Potassium Sustained-Release Tablets and Exploration of Released Character

VernacularTitle:双氯芬酸钾缓释片的研制及释药特性的探讨
Author: Li ZONG ; Bo WANG ; Ning ZHANG
Publication Type:Journal Article
From: Journal of China Pharmaceutical University 2001;(3):206-209
CountryChina
Language:Chinese
Abstract: AIM　Diclofenac potassium sustained-release tablets were developed as a gel matrix for using twice daily and evaluated in vitro release characteristics. METHODS　The formulations were screened according to the designed in vitro release rate by the use of HPMC as the gel matrix and the hydrophobic retarding agent to modify the release. RESULTS　The release was properly characterized by the diffusion mechanism, influenced by pH of the media, slightly affected by the basket rotating speed, without the influences from the pressure exerted during the tabletting procedure. CONCLUSION　The selected formulation of diclofenac potassium sustained-release tablets could ensure the desired in vitro release rate. In addition, it proved a good manufacturing reproducibility.