Pharmacokinetics and Relative Bioavailability of Acyclovir Tablets in Men
- VernacularTitle:阿昔洛韦片在人体中药代动力学及其相对生物利用度研究
- Author:
Lin XIE
;
Lei CHENG
- Publication Type:Journal Article
- From:
Journal of China Pharmaceutical University
2001;(3):210-212
- CountryChina
- Language:Chinese
-
Abstract:
AIM to compare the bioavailability and pharmacokinetics of two acyclovir tablets. METHODS Concentrations of acyclovir in 10 men serum after po 600 mg of two acyclovir tablets were determined , in random 2-way crossover design. Pharmacokinetic parameters were also estimated. RESULTS The peak concentrations of test and reference tablets were 1.24±0.49 and 1.17±0.20 μg/ml, the AUC 7.56±1.80 and 7.56±2.10μg*h/ml, respectively. The relative bioavailability was 101.36%±11.62%. The test formulation was found bioequivalent to the reference in AUC and Cmax by two one-side t test. CONCLUSION Two tablets were bioequivalent.
