Antagonistic Effects of Extracts from Cultural Mycelium of Cordyceps sinensis on Arrhythmia

VernacularTitle:人工虫草提取物抗心律失常作用的研究
Author: Xiaojian GONG ; Hui JI ; Qi CAO ; Shaoping LI ; Ping LI
Publication Type:Journal Article
From: Journal of China Pharmaceutical University 2001;(3):221-223
CountryChina
Language:Chinese
Abstract: AIM　The purpose is to study the anti-arrhythmic effects of extracts from cultured Cordyceps sinensis. METHODS　Aconitine and barium chloride were used to induce experimental arrhythmia models in rats. RESULTS　The results showed that PE was more potent than other ingredients. Pretreatment with PE by oral administration significantly antagonized arrhythmia induced by aconitine. PE significantly prolonged the onset of arrhythmia, decreased the duration and diminished the degree of severity. And in barium chloride-induced arrhythmia model, PE had some anti-arrhythmia effect，which could diminish the degree of severity effectively to some extent. CONCLUSION　PE is an active component to antagonize arrhythmia induced by aconitine and barium chloride.