Study on the Anti-inflammatory Effect of Biota orientalis
- VernacularTitle:侧柏叶醇提取物抗炎作用的研究
- Author:
Tong LIANG
;
Yanmei QIN
;
Nianci LIANG
- Publication Type:Journal Article
- From:
Journal of China Pharmaceutical University
2001;(3):224-226
- CountryChina
- Language:Chinese
-
Abstract:
AIM The purpose is to investigate the Anti-inflammatory mechanism of Biota orientalis. METHODS Using rat leukocytes and rabbit platelets as experimental material the biosynthesis of leukotriene, 12-hydroxyheptadecatrienoic acid(12-HHT) and 12-hydroxyeicosatetraenoic acid(12-HETE) in the cells was determined with HPLC. RESULTS Biota orientalis was shown to inhibit the biosynthesis of leukotriene B4(LTB4) and 5-hydroxyeicosatetraenoic acid(5-HETE) with IC50 of 0.40 and 0.41 mg/ml crude herb, respectively. It was also displayed to inhibit biosynthesis of 12-HHT in the platelets. CONCLUSION Biota orientalis leaves contain anti-inflammatory components and the anti-inflammatory mechanism was related with inhibiting metabolism of arachidonic acid.
