Effect of Nerve Regeneration Factor on GAP-43 and NF-L Gene Expression in Dorsal Roots Ganglia Cell
- VernacularTitle:神经再生素对背根神经节细胞GAP-43和NF-L基因表达的影响
- Author:
Fei DING
;
Mei LU
;
Xiaosong GU
- Publication Type:Journal Article
- From:
Journal of China Pharmaceutical University
2001;(3):231-234
- CountryChina
- Language:Chinese
-
Abstract:
AIM To Detect the varying of gene expression in cultured dorsal root ganglion cells treated by Nerve Regeneration Factor and explore its molecular mechanism promoting to nerve growth. METHODS By RT-PCR, the change of gene expression in GAP-43 and NF-L on the cultured DRG cells with Nerve Regeneration Factor were studied during 4 h, 12 h, 24 h. RESULTS The expression of GAP-43 and NF-L were increased by Nerve Regeneration Factor on DRG′s culture. CONCLUSION This study indicated Nerve Regeneration Factor may up-regulate the gene expression associated nerve growth on cultured nervous cells.
