Improved Synthesis of 2-(3-benzoylphenyl) propionitrile
- VernacularTitle:2-（3-苯甲酰基苯基）丙腈的合成研究
- Author:
Min YU
- Publication Type:Journal Article
- From:
Journal of China Pharmaceutical University
2001;(3):185-186
- CountryChina
- Language:Chinese
-
Abstract:
2-(3-benzoylphenyl)propionitrile which is an important intermediate of ketoprofen was synthesized through phase-transfer catalytic by four steps, involving Friedel-crafts reaction, bromination and cyanation. Pure compound was obtained, and the content of crystal was about 98%.AIM The content of 2-(3-benzoylphenyl)propionitrile was improved. METHODS Phase-transfer catalytic methylation and suitable method of aftertreatment were used. RESULTS The yield and content was both improved. CONCLUSION Phase-transfer catalytic methylation was the best method, and suitable method of aftertreatment was essential.
