Inhibitory effects of domestic incadronate on osteoclastic bone resorption in vitro
10.3969/j.issn.1000-1492.2001.02.007
- VernacularTitle:国产因卡磷酸钠对体外破骨细胞性骨吸收的作用
- Author:
Yan YANG
;
Minzhu CHEN
- Publication Type:Journal Article
- From:
Acta Universitatis Medicinalis Anhui
2001;(2):102-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of domestic incadronate(ICD) on osteoclastic bone resorbing lacunae. Methods Rabbit's osteoclastes were coincubated with bone slices and microphotographed,microdensitometric scanned and analyzed by computer image analysis system. Results ICD (0.5，5 and 50 μmol/L) caused dose-dependent reduction in the number of osteoclastic bone resorbing lacunae. The inhibitory effect ICD (5 μmol/L) was more remarkable than that of aminopropanediphosphonate (APD). Both ICD and APD reduced the surface area of osteoclastic bone resorbing lacunae. The effect of ICD was stronger than that of APD. Conclusion ICD directly suppresses osteoclastic bone resorption and may be effective in osteoporosis.
