Evaluation on efficiency of low molecular weight heparin as a single bolus dose with reused dialyzers
10.3969/j.issn.1000-1492.2001.02.014
- VernacularTitle:透析前注射单剂量低分子量肝素对透析器复用效率的评价
- Author:
Yonggui WU
;
Lanying ZHU
;
Haiping MAO
- Publication Type:Journal Article
- From:
Acta Universitatis Medicinalis Anhui
2001;(2):121-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficiency of low molecular weight heparin(LMWH, fraxiparine) given as a single predialysis bolus injection with reused dialyzers in comparison with standard heparin(SH) administered with a continuous infusion. Methods 30 hemodialysis patients were studied in a radomized crossover fashion. Dialyzers fibrer bundle volumes(FBV), predialysis hemocrit and 2 h clearance of urea, creatinine were observed in the first, the fourth dialysis. The plasma heparin activities(anti-Fxa levels) were measured by the chromogenic substrate assay in 0 h, 2 h, 4 h of dialysis. Results Significant increase (P<0.05) was seen in the number of dialyzer reuse in LMWH group compared with SH group; there was not significant decrease in dialysis FBV as well as 2 h clearance of urea, creatinine (P>0.05); in addition, the plasma heparin activity(anti-Fxa levels) were comparable in both groups after 2 h of dialysis, however, they were significantly higher after 4 h in the LMWH than those in the SH group (P<0.05). Conclusion LMWH as a single bolus dose can prevent decrease in dialyzer clearance. It is clinically worthy of further popularity.
