Changes of serum cortisol concentration in type 2 diabetic patients
10.3969/j.issn.1000-1492.2001.02.017
- VernacularTitle:2型糖尿病患者血清皮质醇浓度的变化
- Author:
Yan CHEN
;
Zuohua XU
;
Wen JIANG
- Publication Type:Journal Article
- From:
Acta Universitatis Medicinalis Anhui
2001;(2):129-130
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assay serum cortisol concentration in type 2 diabetic patients and evaluate the relationship between serum cortisol concentration and insulin resistance. Methods Serum cortisol concentrations were measured at 8 am, 4 pm and during oral glucose tolerance test(OGTT) in 60 newly-onset type 2 diabetic patients and 40 healthy subjects using RIA. Results ① Sernm cortisol concentrations were elevated in obese type 2 diabetic patients at 8 am and 4 pm as compared with non-obese patients and normal controls. ② Changes of serum cortisol concentration during OGTT were different between obese type 2 diabetic and non-obese patients: serum cortisol concentrations were decreased after glucose administration in non-obese patients but not in obese patients. ③ In type 2 diabetic patients, serum cortisol concentrations were negatively correlated with insulin sensitivity index (r=-0.34, P<0.01). Conclusion There is some degree of abnormal in cortisol secretion in obese type 2 diabetic patients.
