Study on the relationship among HBV-DNA detected by PCR,the common types of HBV serum immune markers and Pre-S2
10.3969/j.issn.1671-8348.2001.02.002
- VernacularTitle:PCR检测HBV DNA与HBV血清标志物常见模式和Pre-S2相互关系研究
- Author:
Zhulin LIU
;
Juxian ZOU
;
Tianen CHANG
- Publication Type:Journal Article
- From:
Chongqing Medicine
2001;(2):100-101
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical significance and relationship among Pre-S2、6 common types of HBV serum immune markers(HBV-M)and HBV-DNA.Methods Using PCR to detect HBV DNA and ELISA technique to detect Pre-S2,6 kinds of HBV-M in the meantime.Results Positive infection rates of HBV DNA in 6 common types of the 1484 cases were 89.8%>55.6%>21.8%>7.5%>7.1%>6.8% respectively,namely the model (1)>(3)>(2)>(5)>(6)>(4);but the positive cases of HBV serum immune markers were in the order (2)>(1)>(3)>(4)>(5)>(6).The positive rates were significant difference between Pre-S2 and HBV DNA in (2)、(3) types (P<0.01) and no significant difference in other types(P>0.05).Conclusion It is necessary to detect Pre-S2,HBV DNA and HBVserum immune markers,but HBV serum immune makers and Pre-S2 detected by ELISA only external indication and indirect evidence of HBV infection.While the detection of HBV DNA by PCR was direct evidence of HBV infection.Therefore they have their unique clinicl significance.
