The effects of endotoxemia on hepatic energy metabolism and hepatic tissue blood flow in rats with obstructive jaundice.
10.3969/j.issn.1671-8348.2001.02.007
- VernacularTitle:阻塞性黄疸内毒素血症对肝组织血流和肝能量代谢的影响
- Author:
Qi LUO
;
Zhengjie HUANG
- Publication Type:Journal Article
- From:
Chongqing Medicine
2001;(2):111-113
- CountryChina
- Language:Chinese
-
Abstract:
Objective The effects of endotoxemia on hepatic energy metabolism and hepatic tissue blood flow were studied on the rats with obstructive jaundice.Methods After biliary obstructed and decompressed the rats were injected endotoxin,then hepatic tissue blood flow and energy metabolism were determined.Results Hepatic blood flow decreased and hepatic energy metabolism lowered in rats with obstructive jaundice.Hepatic blood flow decreased markedly and hepatic energy metabolism lowered further due to endotoxemia. Afeter 4 weeks of jaundice hepatic energy metabolism did not recover.Conclusion The decrease in hepatic tissue blood flow affected notably hepatic energy metabolism in obsturctive jaundice.When obstructive jaundice with endotoxemia happened,hepatic tissue blood flow markedly deceased and energy metabolism lowered further.
