Changes of plasma endothelin-1, von Willebrand factor and fibrin D -dim er and their chinical significance in children with schnlein-henoch purpuric nephritis

VernacularTitle:紫癜性肾炎患儿血浆内皮素-1、vWF、D-二聚体的变化及临床意义
Author: Yuzong NIU ; Xiuqin LIU ; Lin HAN ; Jianfang CHU
Publication Type:Journal Article
From: Journal of Clinical Pediatrics 2001;(2):96-98
CountryChina
Language:Chinese
Abstract: Plasma endothelin-1 (ET-1),von Willebrand factor ( vWF) and fibrin D-dimer (D-D) were determined in 14 children with schnlein-henoch purpuric nephritis (SHN),17 children with schnlein-hen och purp ura (SHP, no abnormal finding in the examination of the urinary system) and 12 children as normal controls, respectively. The results showed that plasma ET-1( 88.48±22.96ng/L),vWF(1.59±0.38U/ml) and D-D(1.45±0.39)mg/L in the SH N group were all significantly higher than those in both of the control group (4 3.73±17.89)ng/L, (0.99±0.3)U/ml and (0.28±0.23)mg/L and the SHP group (57. 54±20.92)ng/L, (1.5±0.31)U/ml and (0.64±0.34)mg/L although no significa ntly difference in the levels of vWF was observed between SHN and SHP groups. It was noticed that the levels of three parameters decreased significantly in the SHN g roup after treatment (all P＜0.01). There was a positive correlati on between the levels of plasma ET-1 and D-D with serum creatinine (all P＜0.01). It is suggested that excessive ET-1 induced by endothelial dam age of renal vessels, intravascular coagulation and secondary fibrinolysis are p robably involved in the process of renal damage.