The influeuce of IL-2 on the immunologic function of the NPC patients treated with radiotherapy and chemotherapy
10.3969/j.issn.1001-1781.2001.02.005
- VernacularTitle:白细胞介素2对鼻咽癌放、化疗患者机体免疫功能影响的研究
- Author:
Yongfeng SI
;
Peizhong WANG
;
Wei JIAO
;
Rijing ZHOU
;
Zheng ZHANG
;
Zhuoxia DENG
;
Zhengxian CHEN
;
Zhongqiang TAO
- Publication Type:Journal Article
- From:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
2001;(2):59-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the combining therapy which not only have cured effect but also can uphold and improve the NPC patient′s immunity function after radiotherrapy and chemotherapy.Method:90 cases randomly divided into 3 groups ①Local group (local injected with IL-2 +radiotherapy+chemotherapy);②General group(ivdrip with IL-2+radiotherapy+chemotherapy);③convention group(radiotherapy+chemotherapy).Checked and observed the immunity function around the immunotherapy and after the radiotherapy and chemotherapy.Result:Cellular immunity of 3 groups are lower and humoral immunity are hypetuntion than normal person.After treated with IL-2 the cellular immunity improves but there′s no great change of the humoral immunity. The immune status of the immune groups have not obvious change than before radiotherapy,at the same time,the cellular immunity of the convention group cut down and the humoral immunity doesn′t change obviously.Conclusion:①It has some effect to uphold and improve the NPC patient′s immunity function to treat with small dosage of IL-2 before radiotherapy and chemotherapy,general treatment is better than local injection;②The three therapies have not great influence on the patient′s humoral immunity.
