Clinicopathological analysis and genetic diagnosis of subcutaneous panniculitic T-cell lymphoma
10.3969/j.issn.1001-7399.2001.02.006
- VernacularTitle:皮下脂膜炎样T细胞淋巴瘤的病理分析及基因诊断
- Author:
Xuenong LI
;
Yanqing DING
;
Meigang ZHU
;
Guoping ZHONG
;
Jun ZHOU
- Publication Type:Journal Article
- From:
Chinese Journal of Clinical and Experimental Pathology
2001;(2):113-116
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To explore the clinicopathological features of subcutaneous panniculitic T-cell lymphoma(SPTCL) and significances of genetic analysis in the diagnosis. Methods Histopathology, immunohistochemitry and detection of clonal gene rearrangement by PCR were used in 3 cases of subcutaneous panniculitic T-cell lymphoma (SPTCL), which were originally diagnosed as relapsing nodular nonsuppurative panniculitis. Results Three misdiagnostic cases were correctly redefined as subcutaneous panniculitic T-cell lymphoma, with immunophenotype of CD45+,CD45RO+, Mac387－,and clonal TCR-β gene rearrangement. Conclusions Subcutaneous panniculitic T-cell lymphoma has distinctive clinicopathological features. Genetic analysis is an effective method for the diagnosis of SPTCL.
