Gastrointestinal stromal tumors: A pathomorphologic and immunohistochemical study of 77 cases
10.3969/j.issn.1001-7399.2001.02.009
- VernacularTitle:77例胃肠道间质肿瘤的病理形态学及免疫组化研究
- Author:
Yuanhua CHENG
;
Guanghua YANG
;
Lixin GUO
- Publication Type:Journal Article
- From:
Chinese Journal of Clinical and Experimental Pathology
2001;(2):123-127
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the pathomorphological and immunohistochemical features of gastrointestinal stromal tumors (GIST). Methods Light microscopy was used to study the morphologic characteristics of 77 cases of GIST. The expression of c-kit(CD117), CD34, vimentin, SMA and S-100 protein were detected in all cases with S-P immunohistochemical method. Results GIST tended to have a higher degree of cellularity and lesser degree of cytoplasmic eosinophilia than observed in classic leiomyomas. The neoplastic cells of GIST were spindle, epithelioid or both in different proportion. Focal to prominent cytoplasmic vacuolization was often seen. The histological spectrum included interlacing fascicles, diffuse sheets, storiform and palisading pattern. The formation of cell clusters was rather special. Stromal and vascular hyalinization was common. GIST primary in the mesentery tended to have a higher potentiality of malignancy. The positivity of CD117 and CD34 were 90%, 92%, respectively. Conclusion The characteristic histological features exist in GIST. The detection of CD117 and CD34 is helpful to differential diagnosis.
