Changes of soluble tumor necrosis factor receptors，tumor necrosis factor-alpha in rheumatoid arthritis
10.3969/j.issn.1000-8861.2001.02.013
- VernacularTitle:类风湿关节炎患者血清sTNF-R、TNF-α的变化
- Author:
Ping LI
;
Xianhong LIU
;
Lijuan ZHAO
- Publication Type:Journal Article
- From:
Immunological Journal
2001;(2):119-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between soluble tumor necrosis factor receptors (sTNF-R), TNF-α, TNF-α/sTNF-R and rheumatoid arthritis. Methods Serum levels of sTNF-RⅠ, sTNF-RⅡ and TNF-αwere measured in 28 patients with active RA and 12 patients with inactive RA and 30 healthy controls, using double antibodies sandwiched ELISA. Results The results showed that serum levels of sTNF-RⅠ, sTNF-R Ⅱ and TNF-α were significantly higher in the group of patients with active RA than those found in healthy group and in the patients with inactive RA. Serum levels of both sTNF-RⅠ, sTNF-RⅡ and TNF-α were also significantly higher in patients with inactive RA than in healthy group(P＜0.01 for all). In RA, the serum concentrations of sTNF-RⅠ and sTNF-RⅡ were positively correlated with the levels of ESR，CRP，Ritchie index. Conclusions These results suggest that the serum levels of sTNF-RⅠ and sTNF-RⅡwere significantly increased and positively correlated with the disease activity. The determination of serum levels of sTNF-RⅠ and sTNF-RⅡ can be regarded as a useful laboratory parameter for diagnosis of RA,monitoring of the disease activity and assessment of prognosis.
