Expression of tumor suppressor gene p15, p16 in leiomyosarcoma of soft tissue
10.3969/j.issn.1001-7399.2001.02.012
- VernacularTitle:软组织平滑肌肉瘤中肿瘤抑制基因p15、p16的表达
- Author:
Hui PENG
;
Guanghua YANG
;
Lixin GUO
;
Hong BU
;
Jianmin XU
;
Shiyu ZHANG
- Publication Type:Journal Article
- From:
Chinese Journal of Clinical and Experimental Pathology
2001;(2):133-135
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To investigate the significance of tumor suppressor gene p15 and p16 expression in soft tissue leiomyosarcoma(LMS) and leiomyoma(LM). Methods Expressions of p15 and p16 was studied in 38 cases of LMS and 20 LM with immunohistochemical method. Results The abnormal expression rates of p15 and p16 in LMS were 18.4% and 42.1% respectively, and were significantly different. p15 abnormal expression rate in LM was 60%, significantly higher than in LMS. The total abnormal expression rate of p15 and p16 was 52.6% in LMS studied. Grade Ⅰ tumor had the significantly higher abnormal expression rate than that of grade Ⅱ or Ⅲ tumor. Fifteen cases of LMS were followed. The abnormal expression rate of p15 and p16 in recurrent group was 75%, significantly higher than that in non recurrent group. Conclusions Loss of expression of p16 protein is more frequent in LMS than that of p15, whereas deletion of p15 protein is more frequent in LM than in LMS. Loss of functions of p15 together with p16 participates in the tumorigenesis and progression of LMS, and is correlated with pathologic grading and prognosis of LMS.
