Myocardial pathology,lipid peroxidation and nitric oxide in diabetic rats
10.3969/j.issn.1001-7399.2001.02.016
- VernacularTitle:糖尿病大鼠心肌病理变化及脂质过氧化和一氧化氮的改变
- Author:
Guorong CHEN
;
Sunzhong MAO
;
Jianmin LI
;
Kaiyan YANG
;
Yun HU
- Publication Type:Journal Article
- From:
Chinese Journal of Clinical and Experimental Pathology
2001;(2):146-149
- CountryChina
- Language:Chinese
-
Abstract:
Purpose To study myocardial pathology and its pathogenesis in diabetes. Methods Myocardial structure of alloxan induced diabetic rats was observed under light microscopy (LM)and transmission electron microscopy(TEM).Activity of superoxide dismutase(SOD),glutathione peroxidase (GSH-Px)，nitric oxide synthase(NOS)and content of malondialdehyde (MDA),nitric oxide(NO) were detected biochemically in myocardial homogenate. Results Atrophy and degeneration of myocardium and interstitial fibrosis were found under LM and expansion of mitochondria and smooth endoplasmic reticulum, destruction of myofibril and interstitial proliferation of collogen fiber under TEM. Activity of SOD and GSH-Px decreased significantly, while content of NO and MDA and activity of NOS increased significantly in diabetic rats. Conclusion Atrophy of myocardium, expansion of mitochondria,destruction of myofibril and interstitial fibrosis are the main morphological changes of diabetic cardiomyopathy, and lipid peroxidation and NO may be involved in it.
