Study of gastroenteric mucosa immune responses in Balb／c mice by oral immunization with helicobacter pylori
10.3969/j.issn.1000-8861.2001.02.009
- VernacularTitle:口服幽门螺杆菌苗免疫小鼠后胃粘膜的免疫应答
- Author:
Dongshui LU
;
Changqing YU
;
Quangming ZOU
- Publication Type:Journal Article
- From:
Immunological Journal
2001;(2):107-109
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mucosa immune responses of gastric and intestinal mucosa in Balb／c mice administered orally with Hp sonicate and mucosal adjuvant（LT）．Methods The changes of antigen specific AFC in gastric and intestinal mucosa were detected by ELISPOT assay． Results The numbers of sIgA and IgG AFC rise significantly in PP and gastric mucosa， especially the numbers of sIgA-AFC， significant differences were observed between two immunized groups and the control． Conclusions Locally synthesized specific sIgA antibodies contribute to immunity against gastric helicobacter infection．
