DETECTION OF THE LEVELS OF THE IFN-γ AND TNF-α IN SERUM OF THE PATIENES WITH THE DENGUE VIRUS INFECTION AND ITS CLINICAL SIGNIFICANCE
10.3969/j.issn.1002-2694.2001.02.005
- VernacularTitle:登革病毒感染患者血清IFN-γ和TNF-α的检测及意义
- Author:
Zhenyou JIANG
;
Lifang JIANG
;
Danyun FANG
;
Huiyu GUO
- Publication Type:Journal Article
- From:
Chinese Journal of Zoonoses
2001;(2):19-21
- CountryChina
- Language:Chinese
-
Abstract:
AimTo study the effect of interferon gamma( IFN-γ) and tumor necrosis factor alpha(TNF-α) in the immune pathogenesis of dengue virus infection. Method The serum levels of IFN-γ and TNF-α were measured with emzyme linked immunosorbent assay (ELISA) method in 30 cases of the patients with the dengue virus infection in Guangzhou district. The results were treated with t-test of two sample mean. ResultsThe serum levels of IFN-γ and TNF-α in patients with the dengue virus infection were much higher than healthy controls( P ＜ 0.05、 P ＜ 0.01 ). IFN-γ was detectable on the first day of postinfection. Level of IFN-γ reached their peaks on the second day, then declined . The level of TNF-α had an obvious rise from the second day and reached their peaks on the third day, then declined. ConclusionThe data suggest that the IFN-γ and TNF-α may play an important role in the dengue virus pathogenicity and immunity.
