Sample sizes to Estimate Vaccine Efficacy in Case-Control Study
10.3969/j.issn.1002-3674.2001.02.003
- VernacularTitle:病例对照研究评价疫苗效力的样本含量
- Author:
Fangli YE
;
Jinshan XIA
- Publication Type:Journal Article
- From:
Chinese Journal of Health Statistics
2001;(2):74-76
- CountryChina
- Language:Chinese
-
Abstract:
Objective This paper presents formula for determining the sample size required in case-control study to estimate vaccine efficacy VE with adjusting the precision of confidence interval.Methods Formula to calculate sample size is derived from the principle of relative width of the confidence interval.Results Prespecified relative width may regulate and control the precision of confidence interval and may reflects magnitude of the sample size.Conclusion Sample size calculated by formula will assure that the investigator understand accurately the degree of point estimates of VE close to the true value of VE in the population.
