Study on the quality standard for Liyan granule
- VernacularTitle:利咽颗粒剂质量标准的研究
- Author:
Xinmei CHEN
;
Xihong GUO
- Publication Type:Journal Article
- From:
Chinese Pharmaceutical Journal
2001;(2):125-127
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To establish a quality standard for Liyan granule.METHODS Honeysukle flower in the granule was identified by TLC.The developing agent was the upper solvent of butyl acetate formil acid-water(7∶2.5∶2.5).The dual wavelength spectrophotometry was applied for the determination of chlorogenic acid in granule.And the acute toxicity test was accomplished.RESULT The TLC for the identification of Honeysule flower in the granule was accurate.The uv for chlorogenic acid was reliable.The linear range of chlorogenic acid was 0.46～46.00 μg*mL-1(r=0.9992),and the recovery was 97.33%,RSD=1.49%.The acute toxicity test showed that the maximal tolerable dose in rats was equivalent to 850 times of the clinical dosage in human.CONCLUSION This method could be used as the quality control during the production of Liyan granule.
