Clinicopathologic study on p185 and p16 proteins in human breast cancer
10.3969/j.issn.1000-1492.2001.01.007
- VernacularTitle:p185和p16在乳腺癌中的表达及其意义
- Author:
Yulian LUO
;
Qiang WU
- Publication Type:Journal Article
- From:
Acta Universitatis Medicinalis Anhui
2001;(1):24-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the biological significance of p185 and p16 in breast cancer. Methods Immunohistochemical S-P method was used to detect the expression of p185 and p16 proteins in 59 breast carcinomas，and their relations to clinicopathologic features were analyzed. Results The positive rates of p185 and p16 were 47% and 34% respectively. No significant association was evident between the two proteins. There was also no significant relation between p16 expression and clinicopathologic features. p185 positive rate was 64% in the group of lymph-node involvement that was higher than that being 32% lymph-node negative one (P<0.05). Conclusion p185 and p16 may play important roles independently in the development of breast cancer through different pathways. p185 detection is of important value in breast cancer.
