Study on the relativity of hepatitis C virus infection and hepatocellular carcinoma

VernacularTitle:丙型肝炎病毒感染与HCC相关性的研究
Author: Kexia WANG ; Jian WANG
Publication Type:Journal Article
From: Acta Universitatis Medicinalis Anhui 2001;(1):47-49
CountryChina
Language:Chinese
Abstract: Objective　To study the relationship between HCV infection and hepatocellular carcinoma. Methods　PCR techniques were used to detect the serologic markers of HCV-RNA of 92 patients with hepatocellular carcinoma (HCC), 117 patients with liver cirrhosis (LC) and 100 paraffin-embedded liver tissues from patients from Huainan area. The 89 HCV-RNA positive sera from the 209 patients were analyzed by restriction fragment length polymorphism (RFLP). Results　The infection rates of HCC, LC, liver tissues were 29.3%, 26.5%, 31.0%. HCV genotype of all groups was mainly of type Ⅱ (65.2%) whereas that of type Ⅲ was 31.5%. Conclusion　HCC is associated with the infection of HCV in Huainan area. The infection of HCV type Ⅱ appears to play a main role in the development of HCV-associated HCC and LC in this area.