Changes of β-endorphin in both of plasma and CSF and its significance in children with acute encephaledema following infection of central nervous system
10.3969/j.issn.1000-3606.2001.01.011
- VernacularTitle:急性脑水肿时血浆和脑脊液β-内啡肽的变化及其意义
- Author:
Guangqian LI
;
Hongwen HU
;
Meiqin ZHENG
;
Yali ZHANG
;
Zhongdong LIN
;
Xiuyun YE
- Publication Type:Journal Article
- From:
Journal of Clinical Pediatrics
2001;(1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
To explore the role of β-endorphin (β-EP) in the pathogenesis of the acute encephaledema, the levels of β-EP in both of plasma and CSF were determined by radioimmunoassay in 69 children with infection of central nervous system consisting of 39 cases with encephaledema and 30 cases without encephaledema, respectively. Another 19 cases without intracranial infection were as the control group. The results showed that the levels of plasma and CSF β-EP in the encephaledema group (50.74 ng/L±26.60ng/L，62.72ng/L±39.23ng/L) were significantly higher than those in without encephaledema group (32.78 ng/L±21.2ng/L，34.13ng/L±30.26ng/L)and the normal group (14.83ng/L±6.55ng/L，9.77ng/L±6.33ng/L)，respectively (P＜0.01).It is concluded that β-EP plays an important role in the occurrence and development of encephaledema in children with the infection of central nervous system.
