Chinical assessment of serum cardiac troponin I for the detection of myocardial injury in children with Kawasaki disease in acute stage
10.3969/j.issn.1000-3606.2001.01.026
- VernacularTitle:血清心肌肌钙蛋白I诊断川崎病急性期心肌损伤的临床价值
- Author:
Rongzhou WU
;
Qi CHEN
;
Yuanhai ZHANG
;
Wenwen LU
;
Rulian XIANG
- Publication Type:Journal Article
- From:
Journal of Clinical Pediatrics
2001;(1):48-49
- CountryChina
- Language:Chinese
-
Abstract:
To explore the clinical significance of serum cardiac troponin I (cTnI) for the detection of myocardial injury in children with Kawasaki disease (KD) in acute stage, the levels of serum cTn I, creatine kinase (CK), creatine kinase isoenzyme (CK-MB), lactic dehydrogenase (LDH) and glutamic oxalacetic transaminase (GOT) were determined in 40 children with KD and 23 controlled children without heart disease, respectively. The results showed that the levels of serum cTn I and CK-MB in the KD group were significantly higher than those in the controlled group (P＜0.001),while no obviously differences of CK, LDH and GOT were noticed between two groups (P＞0.05). cTn I was more sensitive comparing to CK-MB for the detection of myocardial injury (P＜0.05). It is concluded that the determination of cTn I and CK-MB will be available for the diagnosis of myocardial injury in children with KD in acute stage, and the determination of cTn I is more sensitivity and specificity comparing to CK-MB.
