p53 protein expression and its prognostic importance in patients with nodal non-Hodgkin's lymphoma.
10.3346/jkms.2000.15.1.59
- Author:
Myung Ju AHN
1
;
Hawk KIM
;
In Soon KIM
;
Jin Kyung PARK
;
Mo Ran KI
;
Chan Kum PARK
Author Information
1. Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Lymphoma;
Non-Hodgkin's;
Genes, p53;
Gene Expression
- MeSH:
Antibodies, Monoclonal;
Cell Cycle Proteins/biosynthesis;
Female;
Gene Expression;
Human;
Immunohistochemistry;
Immunophenotyping;
Lymph Nodes/pathology*;
Lymph Nodes/metabolism*;
Lymphoma, Non-Hodgkin/pathology*;
Lymphoma, Non-Hodgkin/metabolism*;
Lymphoma, Non-Hodgkin/genetics;
Lymphoma, Non-Hodgkin/drug therapy;
Male;
Middle Age/Mpartment of Microbiology;
Prognosis;
Protein p53/immunology;
Protein p53/genetics;
Protein p53/biosynthesis*
- From:Journal of Korean Medical Science
2000;15(1):59-64
- CountryRepublic of Korea
- Language:English
-
Abstract:
To determine whether the p53 expression might be a predictor for treatment sponse and overall survival in nodal non-Hodgkin's lymphoma (NHL), we analyzed e expression of p53 in 69 NHL patients. p53 protein expression was analyzed by munohistochemistry with long-term follow up (1-148 months: median 12.2). p53 pression was noted in 23/69 (33.3%) patients. Complete response (CR) rate to stemic chemotherapy was correlated with stage (I/II) (p=0.038), but not with 3 expression (p=0.2856). Poor overall survival was associated with stage =0.0010) or IPI score (p=0.0076), but not with p53 expression (p=0.8601). From ratification analysis by stage, in stage III/IV patients, the p53 positive oup had a trend to be associated with poor overall survival than the p53 gative group. Multivariate analysis revealed that p53 positive group was sociated with less CR rate compared to the p53 negative group (p=0.046), ereas overall survival was correlated with stage (p=0.0320), not with p53 atus. p53 expression was associated with less CR rate in patients with DLBL. rther studies with large numbers of samples and homogenous group of NHL are eded to determine the prognostic value of cell cycle regulator, p53 in NHL.
