Study on the effect of cyclosporin A on the proliferation of leukemic cells
10.3969/j.issn.1000-3606.2001.01.020
- VernacularTitle:环胞霉素A对白血病细胞增殖的影响
- Author:
Lei SHEN
;
Hai HUANG
;
Jingyan TANG
;
Jing CHEN
;
Yaoping WANG
;
Yazhong ZHU
- Publication Type:Journal Article
- From:
Journal of Clinical Pediatrics
2001;(1):37-39
- CountryChina
- Language:Chinese
-
Abstract:
In order to investigate the potential anti-leukemic effect of cyclosporin A(CsA), MTT method and cell viability assay in vitro were carried out in this study to observe the effect of CsA on the proliferation and cell viability of various leukemic cell lines, such as T-cell Jurkat, Molt-4, CCRF-CEM, Nalm-6, K562 and multi-drug-resistant leukemic cell line K562/AO2. The results fully showed that CsA did possess the same cytotoxic action on all the leukemic cell lines, particularly including multi-drug-resistant leukemic cell line,and could then inhibit the proliferation and cell viability of these leukemic cells, thereby indicating that CsA might be applied as one of the new, safe and effective anti-leukemic agents when used with clinically adoptable dosage in leukemias.
