Effects of preoperative chemotherapy on apoptosis of breast carcinoma at the advanced stage
10.3969/j.issn.1001-7399.2001.01.008
- VernacularTitle:术前经动脉灌注化疗对晚期乳腺癌细胞凋亡的影响
- Author:
Yonge OUYANG
;
Jianliang ZHUANG
;
Jinyang ZHENG
;
Rongyu XU
;
Wenbin CHEN
- Publication Type:Journal Article
- From:
Chinese Journal of Clinical and Experimental Pathology
2001;(1):26-27
- CountryChina
- Language:Chinese
-
Abstract:
To determine the effect of pre-operative chemotherapy on apoptosis in breast cancer and to evaluate its signif icance as a prcgnostic marker. MethodsPatients with breast cancer were divided into preoperative chemotherapy group (40 cases)and control group (42 cases). Two groups were analyzed for the appearance of apoptosis by using TUNEL method and electron mi croscope in tissue sections. ResultsApoptosis occurred in 92.5 % of preoperative chemotherapy group and in 78.5 % of control group. The apoptotic indexes were 19.37 + 6.49 and 9.26 + 5.04 ( P ＜ 0.01 ) respectively. Low apoptotic index was related to disease-free survival of patients with breast cancer (P ＜ 0.01 ). ConclusionThe preoperative chemotherapy can induce apoptcsis of breast cancer and improve disease-free survival.
