Pharmacokinetic study of perlolyrine in rats by means of stable isotope dilution
- VernacularTitle:稳定同位素法研究川芎哚药代动力学
- Author:
Ganghua TANG
;
Guohui JIANG
;
Lianfang ZHENG
- Publication Type:Journal Article
- From:
Chinese Pharmaceutical Journal
2001;(1):45-47
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To determine the pharmacokinetic parameters of perlolyrine in rats.METHODS The plasma concentration and pharmacokinetic parameters of perlolyrine were determined by means of GC-MS with selected ion (m/z 247 and m/z 248) and ［2-15N］perlolyrine(m/z 248) as the internal standard.RESULTS The concentration-time profile of perlolyrine after oral administration of perlolyrine fitted a two-compartment open model.The pharmacokinetic parameters were t1/2α=0.31 h, t1/2β=4.62 h, t1/2ka=0.10 h, tmax=0.34 h, cmax=18.74 ng.mL-1,K12=0.82 h-1, K21=0.38h-1,K10=0.29 h-1,Vb=108.16 L.kg-1,AUC=98.54 ng.h.mL-1,respectively.CONCLUSION The method is constant,sensitive and accurate.It provided a scientific basis for the clinical use of perlolyrine.
