SYNERGISTIC EFFICACY OF ADENOVIRUS-MEDIATED bcl-Xs GENE THERAPY AND TOPOTECAN IN OVARIAN CANCER CELL
10.3781/j.issn.1000-7431.2001.01.003
- VernacularTitle:bcl-Xs基因转移与羟基喜树碱对卵巢癌细胞生长抑制的协同效应
- Author:
He WANG
;
V.baker VICKI
- Publication Type:Journal Article
- From:
Tumor
2001;(1):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the presence of synergistic efficacy between adenovirus mediated bcl-Xs (Adv-bcl-Xs) gene therapy and chemotherapy on ovarian cancer cell. Methods NuTu-19 cells were infected by different titers of Adv-bcl-Xs and were treated with topotecan at the same time. Cell proliferation was measured 3 days later by MTT. Graphical representations of the statistical analyses recorded their interaction in tumor cells. Results The statistical results and graphical representations of the statistical modeling showed that the synergistic antiproliferative activity was present (P＜0.01). Conclusion There were synergistic efficacies between Adv-bcl-Xs gene therapy and Topotecan on ovarian cancer cell.
