Expression of CD44s and CD44v6 in laryngeal squamous cell carcinoma and their significance

VernacularTitle:CD44s及CD44v 6在喉鳞癌组织中的表达
Author: Shuangle WANG ; Qiang YANG ; Baikui XIAO ; Yuanshi JIANG ; Enhe CHEN
Publication Type:Journal Article
Keywords: Antigens CD44 Laryngeal neoplasms Squamous cell carcinoma Lymphatic metastasis
From: Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2000;(10):446-448
CountryChina
Language:Chinese
Abstract: Objective: To study the correlation between the expression of CD44s, CD44v6 and theclinicopathological characters of laryngeal squamous cell carcinoma (LSCC) so as to analyze the role of them inoccurrence and progression of LSCC. Method:Expression of CD44 and CD44v6 in 46 cases of LSCC and 20 casesof adjacent normal tissues was inspected with immunohistochemical SP method. Result:The expression of CD44sincreased significantly in lymphnode metastasis group (94.4％) and stage Ⅲ～Ⅳ group (96.2％),but decreasedin non-lymphnode metastasis group (67.9％) and stage Ⅰ～Ⅱ group (55.0％). The expression of CD44v6 waslower (21.7％),which wasn′t associated with any clinicopathological characters. Conclusion:The role of CD44and CD44v6 in carcinoma maybe dependent on the species,type of carcinoma, and the expression of CD44s maybe a biologic marker to evaluate metastasis of LSCC.