Three cases of pancreas allograft dysfunction.
10.3346/jkms.2000.15.1.105
- Author:
Hun Kyung LEE
1
;
Dong Hae CHUNG
;
Jaegul JUNG
;
Song Chul KIM
;
Duck Jong HAN
;
Kyung Hun KANG
;
Eunsil YU
Author Information
1. Department of Pathology, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Pancreas Transplantation;
Biopsy, Needle;
Transplantation, Homologous;
Graft Rejection;
Fungi;
Cytomegalovirus Infections
- MeSH:
Adult;
Biopsy, Needle;
Case Report;
Female;
Graft Rejection/physiopathology;
Graft Rejection/pathology;
Human;
Male;
Pancreas/physiopathology*;
Pancreas Transplantation/pathology*;
Transplantation, Homologous
- From:Journal of Korean Medical Science
2000;15(1):105-110
- CountryRepublic of Korea
- Language:English
-
Abstract:
We present dincopathologic features of three cases of biopsy-proven pancreas allograft dysfunction in Korea. All patients had advanced insulin-dependent diabetes mellitus (IDDM). Case 1 was a 30-year-old woman who underwent a simultaneous pancreas-kidney transplantation. Urinary infection developed 6 days after the operation, which remitted and reappeared, when urine amylase level was normal. Since the 55th day after the operation, intermittent hematuria has persisted. Cytomegalovirus inclusions were detected on the urinary bladder and grafted duodenal mucosa. The graft was removed due to perforation of the grafted duodenum and panperitonitis. Case 2 was a 27-year-old man undergoing pancreas transplantation alone (PTA). Ten days after the transplatation, the level of 24 urine amylase decreased and the graft was not delineated by 99mTc DTPA scintigraphy. Allograft needle biopsy revealed multiple acinar cell necrosis and mild lymphocytic infiltration which were compatible with mild acute rejection. Case 3 was a 25-year-old man undergoing cadevaric PTA. Three months after the transplantation, graft was removed due to gastric perforation associated with cytomegalovirus and angiodestructive fungal infection. Various causes of pancreas allograft dysfunction can be diagnosed by needle biopsy, thus appropriate biopsy specimen should be taken using improved biopsy technique.
