Efficacy and safety of neural stem cell transplantation for the treatment of Parkinson’s disease
10.3969/j.issn.2095-4344.2013.27.014
- VernacularTitle:神经干细胞移植治疗帕金森病的有效性与安全性
- Author:
Xiaoying ZHANG
- Publication Type:Journal Article
- Keywords:
stem cells;
stem cel transplantation;
neural stem cel;
Parkinson’s disease;
nervous system diseases;
cel transplantation;
tyrosine monooxygenase;
nestin;
activity of daily living;
amplification;
effectiveness;
safety;
stem cel photographs-containing paper
- From:
Chinese Journal of Tissue Engineering Research
2013;(27):5033-5040
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: At present, the clinical application of amplified neural stem cells in the treatment of nervous system diseases is stil in exploratory stage. OBJECTIVE: To investigate efficacy and safety of neural stem cel transplantation for the treatment of Parkinson’s disease. METHODS: The embryonic brain tissues aged 12 weeks were obtained for proliferation in vitro, then the brain tissues (5×106-2×107) were prepared into the 4-6 mL suspension. The suspension was injected into 30 cases of Parkinson’s disease through lumbar puncture and carotid injection, once a week, continuously for 3 weeks. Unified Parkinson’s disease rating scale, Hoehn-Yahr scale and Schwab & England Activities of Daily Living Scale scoring were performed prior to and after transplantation. Blood and urine routine, liver function, renal function and adverse reactions were detected and evaluated prior to and after transplantation. RESUTLS AND CONCLUSION: The 12-week-old embryos cultured neural stem cells could be stably amplified in vitro with the capacities of differentiation into neurons, astrocytes and oligodendrocytes. The fol ow-up results showed that neural stem cel transplantation could effectively control the pathological process of Parkinson’s disease, restore the damaged brain function, and improve the patient’s neurological function without significant complications. It is feasible and effective to use the in vitro long-term amplified human neural stem cel transplantation in the treatment of Parkinson’s disease.
