Safety and clinical application of induced pluripotent stem cells
10.3969/j.issn.2095-4344.2013.27.021
- VernacularTitle:诱导性多潜能干细胞的安全性及临床应用*★
- Author:
Yang ZHANG
;
Xiulan LI
- Publication Type:Journal Article
- Keywords:
stem cells;
stem cell academic discussion;
induced pluripotent stem cells;
safety;
reprogramming;
gene;
virus;
smal molecular compound;
clinical application;
diseases;
provincial grants-supported paper
- From:
Chinese Journal of Tissue Engineering Research
2013;(27):5087-5093
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Induced pluripotent stem cells are obtained from somatic cells by reprogramming method. The safety of induced pluripotent stem cells has attracted much attention because of their huge and potential value in clinical application. OBJECTIVE: To review the current studies addressing the safety and clinical application of induced pluripotent stem cells. METHODS: The PubMed database between 2006 and 2012 was retrieved by the first author to search the correlative documents concerning the safety and clinical application of induced pluripotent stem cells. Total y 203 papers were primarily gotten. Final y, 47 papers were included. RESULTS AND CONCLUSION: At present, the main methods to enhance the safety of induced pluripotent stem cells include avoiding usage of c-Myc gene, another mediate way replacing the retrovirus, direct leading of reprogramming factor protein, safer donor cells, micromolecule compound and other in-transgenosis ways. Induced pluripotent stem cells have extensive clinic treatment prospects, and can be used for the build of disease-specific induced pluripotent stem cells line.
