Does Dlx abnormal expression regulate the migration of cranial neural crest cells and development of the first brachial arch?
10.3969/j.issn.2095-4344.2013.28.022
- VernacularTitle:Dlx基因表达改变可影响颅神经嵴细胞迁移及第一鳃弓的发育？***★
- Author:
Zhixu LIU
;
Hao SUN
;
Xudong WANG
- Publication Type:Journal Article
- Keywords:
tissue construction;
tissue construction review;
oral tissue construction;
Dlx;
cranial neural crest cells;
cell migration;
Fgf;
Dlx over-expression;
osteogenesis;
chondrogenesis;
National Natural Science Foundation of China
- From:
Chinese Journal of Tissue Engineering Research
2013;(28):5236-5242
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Dlx gene family is highly expressed in the cranial neural crest cells, and regulates the cranial neural crest cel migration and differentiation. OBJECTIVE: To review the mechanism that the highly-expressed Dlx genes mediate the cranial neural crest cel migration and differentiation. METHODS: An online search of CNKI and Medline databases was performed for articles published before 2013 using keywords of “cranial neural crest cells, migration of cranial neural crest cells, Dlx, Dlx overexpression, Fgf, chodrogenesis, osteogenesis” in Chinese and English, respectively. Relevant articles were summarized from three aspects: the migration of cranial neural crest cells, Dlx over-expression’s impact on the migration of cranial neural crest cells, interaction between the environment and Dlx genes. A total of 63 articles were included. According to inclusion criteria, 43 articles were retained at last. RESULTS AND CONCLUSION: Dlx abnormal-expression wil lead to cel -cel adhesion. Dlx over-expression wil induce most of the cranial neural crest cells aggregate and migrate to a wrong place, and result in skeletal dysmorphology. Dlx over-expression wil also lead to ectopic chondrogenesis, and the interaction between cel factors can be the possible reason for this.
